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PDRN Explained: What Tissue Regeneration Really Means

Polydeoxyribonucleotide has become a buzzword. Here is the biology behind it, without the hype.

Dr. Elena Ricci · 4 min read · 01 July 2026

PDRN is a salmon-derived DNA fragment that binds adenosine A2A receptors, triggering the signaling cascade behind tissue regeneration and wound repair. It has been studied for its role in accelerating healing by increasing vascular endothelial growth factor production, which improves microcirculation and collagen synthesis at the site of application.

That is a specific, testable mechanism — not a claim that any single product reverses ageing. Results vary by patient, and protocols should always be defined by the treating professional.